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Amitriptyline 10mg tabs, and a placebo. The total number of subjects in each group was 32. For the placebo-controlled study, subjects were randomly assigned to 1 of the following conditions: 1) placebo (placebo-treatment); 2) a 12-week treatment with either an antidepressant (intervention) or placebo (placebo); 3) a 14-week treatment with either an antidepressant (intervention) or placebo (placebo). A was administered to each subject in the initial week of study and thereafter until the end of treatment. On study days 7 and 28, the subjects received either 12-step program or placebo. The intervention-group subjects performed 4 treatment sessions (each lasting 30 min); for the amitriptyline over the counter uk placebo-treated subjects, 3 treatment sessions (the first 15 min of each session was dedicated to the 12-step program) were performed. 4 treatment sessions consisted of the following: 1. 10-min walking task (Step) (Pelvic floor, leg raised to knee level for 30 s). 2. 5-min silent reading in the morning (Kneeling), after a 5-min break (10-min silent reading). 3. 10-min walking task (Step), followed by the reading (Kneeling); then, task was repeated a second time in the afternoon with a 5-min break (after the 12-step program session). 4. 10-min silent reading in the morning (Kneeling), after a 5-min break (10-min silent reading). At the completion of 8-week treatment period, patients were asked to complete a questionnaire concerning their experience during treatment with antidepressants. Subjective measures. The patient's report of depressive symptoms was assessed at baseline, 6, 8, 9, and 12 months. The baseline assessment was administered at the start of intervention and at every subsequent visit. Patients were given a questionnaire on their experience during the first treatment session; for each session they had to rate the number of items depression (Depression Scale) that they had associated with symptoms of depression (for example, feeling guilt, of powerlessness, or being unable to trust the other person). These items were summed to yield the overall score of patient (the Patient-Rating Inventory) and used for the analysis of this measure over the time course of study. The Hamilton Depression Rating Scale (HDRS) was used to determine the severity of depressive symptoms during the treatment period (Table 1). HDRS has been validated using a large sample of patients undergoing treatment with antidepressants (19). TABLE 1. HDRS Hamilton Symptom Index (HSRI) Total score Mean (SD) Time (h) Change (baseline) 6.2 (7.5) 1.6 (1.2) 7.1 (4.0) 0.0 Change from baseline to 12 months 3.0 (4.1) 0.8 (0.6) 5.7 (3.4) −0.3 View Large TABLE 1. HDRS Hamilton Symptom Index (HSRI) Total score Mean (SD) Time (h) Change (baseline) 6.2 (7.5) 1.6 (1.2) 7.1 (4.0) 0.0 Change from baseline to 12 months 3.0 (4.1) 0.8 (0.6) 5.7 (3.4) −0.3 HDRS Hamilton Symptom Index (HSRI) Total score Mean (SD) Time (h) Change (baseline) 6.2 (7.5) 1.6 (1.2) 7.1 (4.0) 0.0 Change from baseline to 12 months 3.0 (4.1) 0.8 (0.6) 5.7 (3.4) −0.3 View Large Study design. The study was a 4-period study. The baseline assessments were taken at baseline, 6, 8, 9, and 12 months. On each study day, subjects received the 1-week treatment with antidepressant or placebo. After the 1-week treatment, subjects were reassessed and the study was repeated if any symptoms persisted. Each time the study was repeated results were similar (Supplementary Figure 1). Psychometric evaluation. The Hamilton Depression Rating Scale, as well Amitriptyline 25mg $41.72 - $0.46 Per pill the HDRS and HSRI, in 4 treatment periods were administered at baseline and every subsequent visit. Statistical analysis. The Mann-Whitney test was used to determine treatment differences across time and for the 4 treatment periods. All statistical analyses were performed with the SAS statistical software package.

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